Course Title Chemistry Of Biomolecules
Course Level 200
Credit Unit 2

INTRODUCTION 

Metabolism is the sum of the chemical reactions that take place within each cell of a living organism and that provide energy for vital processes and for synthesizing new organic material. This course describes how the foods we eat are metabolized for the production of energy in the form of ATP for cellular work as well as the synthesizing new organic material. It also describes the inborn errors of metabolism. 

COURSE CONTENT 

Amino acids as building blocks; Biosynthesis of amino acids and derivatives; Oxidative degradation of amino acids and metabolism of one carbon units; Ketogenicity and glucogenicity; Urea cycle, Metabolism of inorganic nitrogen. Disorders and Inborn errors of amino acid metabolism. Creatine and creatinine metabolism. Protein catabolism. Degradation and digestion of carbohydrates; sugars, storage polysaccharides and cell walls. Reactions of sugars. Glycolysis, the tricarboxylic acid cycle, the phosphogluconate pathway, the glyoxylic acid cycle, the pentose phosphate pathway and cori cycle, the Calvin pathway, Glucogenesis, glycogenesis, and glycogenolysis. Regulation of Carbohydrate metabolism. Disorders of carbohydrate metabolism. Purine and pyrimidine synthesis and catabolism and their regulations. Conversion of ribonucleotides to deoxyribonucleotides. Abnormalities in nucleic acid metabolism, xeroderma, pigmentation and skin cancer. Biosynthesis and Oxidation of lipids and lipids derivatives; Beta, alpha and omega oxidation of fatty acids and triglyceride, fatty acid and triglyceride synthesis. 

EXPECTATIONS 

1. Define the terms metabolism, metabolic pathway, catabolism, and anabolism. 

2. Understand how ATP is formed from ADP and inorganic phosphate (Pi), and vice versa. 

3. Name the products formed during the digestion of polysaccharides, triglycerides, and proteins, and know the part(s) of the digestive tract where each occurs. 

4. Understand how the body controls blood glucose concentration by the release of insulin or glucagon into the bloodstream. 

CONCLUSION 

This course will provide insight on how foods are metabolized for the production of energy in the form of ATP for cellular work as well as the synthesizing new organic material. It will describe the inborn errors of metabolism.