Course Title Clinical Biochemistry
Course Level 400
Credit Unit 2

This lecture based course will introduce students to understand what clinical biochemistry is all about and be taught biochemical aspect of diagnosis and therapeutics, Acid/Base balance, blood buffer, metabolic acidosis/alkalosis, plasma enzymes in clinical diagnosis, function test e.g. in liver and kidneys, clearance studies and homeostasis. The course will also expose the students to disorders of iron metabolism, purine/pyrimidine degradation, biomarkers for disease detection, gene therapy, and regenerative medicine. In addition, the course will provide the students with information on chemotherapy of bacterial infections, parasite infections, antifungal and antiviral agents and chemotherapy of neoplastic diseases, molecular mechanism of disease pathogenesis, with a special focus on selected inherited, autoimmune and multifunctional disorders, metabolic diseases, abnormal hemoglobin, the course will also provide knowledge on chemistry and functions of body fluids including cerebral fluid, synovial fluids, etc. finally the student will be taught the biochemical analysis of selected  diseases; atherosclerosis and lipid metabolism, cancer and oncogenes, apoptosis and the cell cycle, human immunodeficiency virus replication and acquired immune deficiency syndrome

Expectation

At the end of the course the students should be able to: 

  1. Define the term clinical biochemistry 
  2. Describe biochemical aspect of diagnosis and therapeutics
  3. Explain disorders in iron and purine/pyrimidine metabolism,
  4. Identify chemotherapy of diseases 
  5. Analyze data obtained from acid/base systems
  6. Calculate pH, pka concentrations of the buffers systems in the body.
  7. Explain the chemistry and functions of body fluids
  8. Derive the Henderson-Hasselbalch equation
  9. Analyze biochemically some selected diseases